Let’s Tox About it – Which neurotoxin is right for me?

Here at R3 health we offer the leading neurotoxin (“Tox”) brands: Botox®, Dysport® XEOMIN® and Jeuveau®. With so many Tox options available, it may seem overwhelming to decide what product best suites your needs. That’s where we come in! Meeting with one of our team’s aesthetic practitioners can help ensure you are getting the Tox that is right for you. Our consultations are quick and easy, designed to understand what you are looking to address, get a look at your facial anatomy and its muscle movements as well as talking through the different brands of neurotoxins.

Let’s chat Tox!

Neurotoxins, or Tox, are the most common injectable in the U.S. Often referred to simply as “botox”, there are four FDA approved botulinum toxins: Botox®, Dysport®, Jeuveau® and XEOMIN®.

Mechanism of Action of Botulinum Toxin Injections

The commonality between all these brands is that they contain the same primary active ingredient known as Botulinum Toxin Type A (BoNT) which is used to reduce the appearance of fine lines and wrinkles by injecting directly into the muscles to prevent contraction. On average, botulinum injections last around 3-4 months.

Differentiating between Injections

While all these injections are designed to improve fine lines and wrinkles, they are all produced by different manufacturers and have unique formulas which affects dosage, application and longevity of each product.

Botox® (onabotulinumtoxinA)

  • Background: Botox®, was FDA approved in 2002 which made it the first official treatment of fine lines and wrinkles. In addition to this, Botox®, can be used to treat hyperhidrosis (excessive sweating), migraines and temporomandibular joint (TMJ) disorders. Allergan is the manufacturer of Botox® and holds about 80% of the injectable market.
  • Formula: Botox® has a molecular weight of 900kDa and is formulated with human albumin and sodium chloride. The formulation contains protective proteins which may cause a subset of patients to develop resistance to the product therefore lessening the effectiveness.
  • Results: Botox® takes about 3-5 days post-treatment for results to be apparent but can take up to two weeks for final effects. Longevity of treatment depends on a variety of factors including a patient’s metabolism, level of activity and area(s) being treated.

Dysport® (abobotulinumtoxinA)

  • Background: Manufactured by Galderma, Dysport® came around seven years later in 2009 which made it the second botulinum toxin type A to hit the market.
  • Formula: Dysport® has a slightly lighter molecular weight than Botox® at 800kDa. Similar to Botox®, Dysport is formulated with human albumin, but it also contains lactose and cow’s milk protein which does not make it suitable for patients with an allergy to milk. Unlike Botox®, the protective proteins in Dysport® are not uniform making Dysport® probability of diffusion which can become important when treating larger surface areas (i.e forehead).
  • Results: Dysport® onset is known to be faster than Botox®, as quick as within 24 hours post treatment with a duration of up to 5 months which makes it a good last-minute option. Dysport is a great choice for younger patients as it provides a more complete relaxation of wrinkles.

XEOMIN® (incobotulinumtoxinA)

  • Background: First approved by the FDA in 2010, XEOMIN® can be used to treat blepharospasms (involuntary blinking), cervical dystonia (involuntary contraction of neck muscles), upper limb spasticity and chronic sialorrhea (excessive drooling)
  • Formula: XEOMIN® is known as the purest botulinum toxin because it does not contain any additives. Studies though have not been performed to determine whether the presence or absence of unnecessary proteins influences efficacy of the product. Because some patients may develop resistance to Botox® or Dysport®, XEOMIN® is often a favorable alternative.
  • Results: XEOMIN® can take up to 4 days to show results, which makes it the slowest out of the neurotoxins. It has been reported that XEOMIN® causes less of a heavy feeling as compared with Botox or Dysport.

Jeuveau®

  • Background: Created by Evolus, Jeuveau® referred to as “NewTox” was approved for use in 2019.
  • Formula: Jeuveau® holds similar properties to that of Botox. It carries the same 900kDa molecular weight as well as being formulated with human albumin and sodium chloride.
  • Results: Due to the novelty of the product there is limited clinical data, but the safety and efficacy profile shows to be like that of Botox. This product is good for all ages and has a quick onset.

The Right Fit for You is Here at R3 Health

There’s a type of Tox out there to meet everyone’s needs, whether you’re looking for a small touch up or a full-on facial freeze. That’s why the consultation process is so crucial in making sure you get your desired results. At the end of the day, Botox®, Dysport®, XEOMIN® and Jeuveau® are all great and effective choices at smoothing out fine lines and wrinkles and our R3 Health team is here to educate you on making the best decision for your wants and needs. Call today, (561) 331-2983, and schedule your complementary Tox consultation.

Sources:

US Food and Drug Administration. Highlights of Prescribing Information – DYSPORT.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/125274s107lbl.pdf

US Food and Drug Administration. Highlights of Prescribing Information – XEOMIN.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125360s073lbl.pdf

American Board of Cosmetic Surgery. Botox-Type Injectables Guide.

https://www.americanboardcosmeticsurgery.org/procedure-learning-center/non-surgical/guide-botox-type-injectables/

Here at R3 health we offer the leading neurotoxin (“Tox”) brands: Botox®, Dysport® XEOMIN® and Jeuveau®. With so many Tox options available, it may seem overwhelming to decide what product best suites your needs. That’s where we come in! Meeting with one of our team’s aesthetic practitioners can help ensure you are getting the Tox that is right for you. Our consultations are quick and easy, designed to understand what you are looking to address, get a look at your facial anatomy and its muscle movements as well as talking through the different brands of neurotoxins.

Let’s chat Tox!

Neurotoxins, or Tox, are the most common injectable in the U.S. Often referred to simply as “botox”, there are four FDA approved botulinum toxins: Botox®, Dysport®, Jeuveau® and XEOMIN®.

Mechanism of Action of Botulinum Toxin Injections

The commonality between all these brands is that they contain the same primary active ingredient known as Botulinum Toxin Type A (BoNT) which is used to reduce the appearance of fine lines and wrinkles by injecting directly into the muscles to prevent contraction. On average, botulinum injections last around 3-4 months.

Differentiating between Injections

While all these injections are designed to improve fine lines and wrinkles, they are all produced by different manufacturers and have unique formulas which affects dosage, application and longevity of each product.

Botox® (onabotulinumtoxinA)

  • Background: Botox®, was FDA approved in 2002 which made it the first official treatment of fine lines and wrinkles. In addition to this, Botox®, can be used to treat hyperhidrosis (excessive sweating), migraines and temporomandibular joint (TMJ) disorders. Allergan is the manufacturer of Botox® and holds about 80% of the injectable market.
  • Formula: Botox® has a molecular weight of 900kDa and is formulated with human albumin and sodium chloride. The formulation contains protective proteins which may cause a subset of patients to develop resistance to the product therefore lessening the effectiveness.
  • Results: Botox® takes about 3-5 days post-treatment for results to be apparent but can take up to two weeks for final effects. Longevity of treatment depends on a variety of factors including a patient’s metabolism, level of activity and area(s) being treated.

Dysport® (abobotulinumtoxinA)

  • Background: Manufactured by Galderma, Dysport® came around seven years later in 2009 which made it the second botulinum toxin type A to hit the market.
  • Formula: Dysport® has a slightly lighter molecular weight than Botox® at 800kDa. Similar to Botox®, Dysport is formulated with human albumin, but it also contains lactose and cow’s milk protein which does not make it suitable for patients with an allergy to milk. Unlike Botox®, the protective proteins in Dysport® are not uniform making Dysport® probability of diffusion which can become important when treating larger surface areas (i.e forehead).
  • Results: Dysport® onset is known to be faster than Botox®, as quick as within 24 hours post treatment with a duration of up to 5 months which makes it a good last-minute option. Dysport is a great choice for younger patients as it provides a more complete relaxation of wrinkles.

XEOMIN® (incobotulinumtoxinA)

  • Background: First approved by the FDA in 2010, XEOMIN® can be used to treat blepharospasms (involuntary blinking), cervical dystonia (involuntary contraction of neck muscles), upper limb spasticity and chronic sialorrhea (excessive drooling)
  • Formula: XEOMIN® is known as the purest botulinum toxin because it does not contain any additives. Studies though have not been performed to determine whether the presence or absence of unnecessary proteins influences efficacy of the product. Because some patients may develop resistance to Botox® or Dysport®, XEOMIN® is often a favorable alternative.
  • Results: XEOMIN® can take up to 4 days to show results, which makes it the slowest out of the neurotoxins. It has been reported that XEOMIN® causes less of a heavy feeling as compared with Botox or Dysport.

Jeuveau®

  • Background: Created by Evolus, Jeuveau® referred to as “NewTox” was approved for use in 2019.
  • Formula: Jeuveau® holds similar properties to that of Botox. It carries the same 900kDa molecular weight as well as being formulated with human albumin and sodium chloride.
  • Results: Due to the novelty of the product there is limited clinical data, but the safety and efficacy profile shows to be like that of Botox. This product is good for all ages and has a quick onset.

The Right Fit for You is Here at R3 Health

There’s a type of Tox out there to meet everyone’s needs, whether you’re looking for a small touch up or a full-on facial freeze. That’s why the consultation process is so crucial in making sure you get your desired results. At the end of the day, Botox®, Dysport®, XEOMIN® and Jeuveau® are all great and effective choices at smoothing out fine lines and wrinkles and our R3 Health team is here to educate you on making the best decision for your wants and needs. Call today, (561) 331-2983, and schedule your complementary Tox consultation.

Sources:

US Food and Drug Administration. Highlights of Prescribing Information – DYSPORT.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/125274s107lbl.pdf

US Food and Drug Administration. Highlights of Prescribing Information – XEOMIN.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125360s073lbl.pdf

American Board of Cosmetic Surgery. Botox-Type Injectables Guide.

https://www.americanboardcosmeticsurgery.org/procedure-learning-center/non-surgical/guide-botox-type-injectables/