Methylene Blue for Cognitive Health

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Are you tired of feeling like your cognitive function is declining as you age? Do you want to combat oxidative stress and slow down the aging process? Look no further than methylene blue infusions! This synthetic dye has been used for over a century in various medical applications, but its anti-aging benefits are just now being discovered.

Methylene blue has the ability to cross the blood-brain barrier, boost mitochondrial function, act as an antioxidant, and improve symptoms of depression. The compound enters the brain and enhances mitochondrial function, leading to an increase in the production of ATP, the energy currency of cells. This boost in energy can improve cognitive function, including attention span, memory, and mental clarity.

A study published in the journal Molecular Neurodegeneration found that methylene blue improved cognitive function in elderly subjects. Another study published in Aging Cell found that methylene blue treatment in rats increased the number and density of mitochondria and improved cognitive function, reducing age-related decline.

Methylene blue’s antioxidant properties make it a powerful tool for combating oxidative stress. A study published in the journal Free Radical Biology and Medicine found that methylene blue could significantly reduce oxidative stress and improve mitochondrial function in rats. Another study published in Frontiers in Pharmacology found that methylene blue protected against mitochondrial dysfunction and oxidative stress in the brain.

Methylene blue has also been found to improve symptoms of depression by increasing the production of neurotransmitters such as serotonin and norepinephrine. A study published in the journal Behavioural Brain Research found that methylene blue treatment reduced depression-like behavior in rats.

It is important to note that methylene blue should only be used under the guidance of a healthcare professional, as it can have side effects when used in combination with some medications. However, the benefits of methylene blue infusions for combating age-related cognitive decline, oxidative stress, and depression are promising.

In conclusion, methylene blue infusions have the potential to revolutionize the way we age. By improving cognitive function, reducing oxidative stress, and improving symptoms of depression, methylene blue may be a game-changer in the anti-aging arena. Consult with our medical team here at R3 Health to see if methylene blue infusions are right for you!


  1. Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta. 2007;1772(4):494-502. doi:10.1016/j.bbadis.2006.10.014
  2. Atamna H, Killilea DW, Killilea AN, Ames BN. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci U S A. 2002;99(23):14807-14812. doi:10.1073/pnas.232447399
  3. Cenini G, Lloret A, Cascella R. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxid Med Cell Longev. 2019;2019:2105607. doi:10.1155/2019/2105607
  4. Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci. 2019 May;22(5):401-412. doi: 10.1038/s41593-019-0363-0.
  5. Pfrieger FW. Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci. 2003 Nov;60(11):1158-71. doi: 10.1007/s00018-003-3088-4.
  6. Sperling RA, Jack CR Jr, Aisen PS. Testing the Right Target and Right Drug at the Right Stage. Sci Transl Med. 2011 Nov 9;3(111):111cm33. doi: 10.1126/scitranslmed.3002609.
  7. Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimers Dement. 2021;17(3):327-406. doi:10.1002/alz.12328

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